Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN1 All Species: 5.45
Human Site: S378 Identified Species: 12
UniProt: P18031 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.3
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P18031 NP_002818.1 435 49967 S378 R S R V V G G S L R G A Q A A
Chimpanzee Pan troglodytes XP_512196 415 48479 R357 R K R I R E D R K A T T A Q K
Rhesus Macaque Macaca mulatta XP_001096290 435 49928 S378 R S R V V G G S L R G A Q A A
Dog Lupus familis XP_534455 424 48717 P354 I K E E T R T P L N V P C S V
Cat Felis silvestris
Mouse Mus musculus P35821 432 49575 G375 E V R R R M V G G G L Q S A Q
Rat Rattus norvegicus P20417 432 49656 M373 D T E V R K R M V G G G L Q S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508429 545 61767 R379 Q D T G V R R R T V G E H Q R
Chicken Gallus gallus O13016 434 50316 R377 Q D T E I R R R T V G E N L H
Frog Xenopus laevis NP_001086085 428 49306 T370 A E S A R P D T E M R R R A V
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W0G1 548 62086 L396 D S R P L P P L P V R A F N D
Honey Bee Apis mellifera XP_392429 495 55903 L366 T G P P D K P L P R E P S I Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 54 97.6 88.5 N.A. 82.9 84.3 N.A. 58.1 78.1 70.8 N.A. N.A. 34.1 40 N.A. N.A.
Protein Similarity: 100 69.8 99 92.8 N.A. 90.5 90.8 N.A. 66.2 86.9 82.3 N.A. N.A. 49.4 57.1 N.A. N.A.
P-Site Identity: 100 13.3 100 6.6 N.A. 13.3 13.3 N.A. 13.3 6.6 6.6 N.A. N.A. 20 6.6 N.A. N.A.
P-Site Similarity: 100 20 100 13.3 N.A. 13.3 33.3 N.A. 20 20 20 N.A. N.A. 26.6 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 10 0 0 0 0 0 10 0 28 10 37 19 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 19 19 0 0 10 0 19 0 0 0 0 0 0 0 10 % D
% Glu: 10 10 19 19 0 10 0 0 10 0 10 19 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 10 0 10 0 19 19 10 10 19 46 10 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % H
% Ile: 10 0 0 10 10 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 0 19 0 0 0 19 0 0 10 0 0 0 0 0 10 % K
% Leu: 0 0 0 0 10 0 0 19 28 0 10 0 10 10 0 % L
% Met: 0 0 0 0 0 10 0 10 0 10 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 10 0 0 10 10 0 % N
% Pro: 0 0 10 19 0 19 19 10 19 0 0 19 0 0 0 % P
% Gln: 19 0 0 0 0 0 0 0 0 0 0 10 19 28 19 % Q
% Arg: 28 0 46 10 37 28 28 28 0 28 19 10 10 0 10 % R
% Ser: 0 28 10 0 0 0 0 19 0 0 0 0 19 10 10 % S
% Thr: 10 10 19 0 10 0 10 10 19 0 10 10 0 0 0 % T
% Val: 0 10 0 28 28 0 10 0 10 28 10 0 0 0 19 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _